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FOLFOXIRI Plus Cetuximab Versus FOLFOXIRI Plus Bevacizumab in Conversion Therapy of Right-sided Colon Cancer Liver Metastases

FOLFOXIRI Plus Cetuximab Versus FOLFOXIRI Plus Bevacizumab in Conversion Therapy of Right-sided Colon Cancer Liver Metastases

Recruiting
18-75 years
All
Phase 2
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  • Simplified (AI rewritten)

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Overview

To compare the efficacy of FOLFOXIRI plus Cetuximab and FOLFOXIRI plus Bevacuzumab in the conversion therapy of right-sided colon cancer liver metastases

Eligibility

Inclusion Criteria:

  • ECOG perfomance 0-1
  • pathologically confirmed colorectal carcinoma, with RAS wild type
  • inital unresectable liver metastases discussed by MDT
  • prior no systemical therapy or exceed 6 months after the adjuvant chemotherapy of primary tumor surgery.
  • without extraheptic metastatic lesions, except for locally controlled lung metastases (RFA or SBRT)
  • adequate blood, liver and renal function
  • expected survival longer than 6 months

Exclusion Criteria:

  • with bleeding risk
  • interestinal obstruction or disease
  • uncontrolled hypertension and severe heart disease
  • previous severe thrombotic events
  • central nervous system metastases
  • accompanied with other malignant tumor

Study details
    Liver Metastasis Colon Cancer

NCT04832776

Fudan University

27 January 2024

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