Overview
- To investigate the etiology and epidemiology of acute kidney injury (AKI).
- To find out risk factors associated with the occurence of AKI.
- To find out risk factors related to the prognosis of AKI,focusing on uremic toxins, inflammation, oxidative stress and nutritional status.
- To study on the relationship between gene polymorphism and prognosis of acute kidney injury.
Description
- To investigate the relationship between preexisting protein-energy wasting (PEW) and adverse outcomes in patients with AKI.
- To evaluate the association of serum nutritional variables and prognosis of AKI.
- Given the different half-lives of serum nutritional markers, we hypothesized that the utility of serum nutritional variables as prognostic predictors may differ in early death (<7 days) and late death (>7 days, <28 days) patients.
- To investigate the various kinds of uremic toxins in AKI, furthermore, to evaluate the relationship between uremic toxins, especially protein bound toxins, and short- or long-term mortality in AKI patients.
- To investigate the mineral bone disorders in AKI,and to evaluate whether these markers would role as prognostic predictors of AKI.
- Several risk factors of mortality in AKI,such as markers of PEW, inflammation and serum creatinine,have been used; however, no single indicator is considered to be a "gold standard."
Eligibility
Inclusion Criteria:
- age >=18 years and <= 88 years
- clinically diagnosed with acute kidney injury, according KDIGO criteria.
Exclusion Criteria:
- preexisting chronic kidney failure (defined as an eGFR <60 ml/min per 1.73 m2)
- post-renal obstruction or rapid progressive glomerulonephritis as the main cause of AKI
- known acute renal dysfunction
- hospital stays <24 hours
- malignancy