Overview
The purpose of this study is to prospectively study patients with Cushing's syndrome before and after treatment, with a special emphasis on physical function, quality of life, and circadian rhythms.
The hypotheses are:
- Cushing's syndrome negatively impacts health-related quality of life (HRQoL) and physical functioning
- Cushing's syndrome is associated with altered circadian rhythms at the whole body level and in peripheral target tissues.
- These complications partially reverse following disease control.
Eligibility
Inclusion Criteria:
- New (≤ 2 months) diagnosis of Cushing's syndrome (CS) of endogenous etiology:
- ACTH-dependent CS
- ACTH-independent CS
- Age >18 years
- Written informed consent
Exclusion Criteria:
- Active cancer
- Iatrogenic or malignant cause of CS such as adrenocortical carcinoma
- Chronic heart failure (New York Heart Association class IV)
- Chronic kidney disease Chronic Kidney Disease stage ≥3 (eGFR >30 ml/min)
- Liver disease in the form of cirrhosis
- Deemed unable to complete the study safely by investigator