Overview
This is a phase II, multicenter, randomized open-label and comparative trial designed to study the effectiveness and the safety of androgen receptor antagonist (darolutamide) combined with surgery in patients with high-risk and/or locally advanced prostate cancer.
In this trial, patients will be assigned in one of the two following treatments arms:
- Arm A (control arm): Surgery alone (radical prostatectomy with lymph node dissection)
- Arm B (experimental arm): Peri-operative darolutamide + surgery (radical prostatectomy with lymph node dissection)
A total of 240 patients will have to be randomized with 120 patients in the control arm and 120 patients in the experimental arm.
Eligibility
Inclusion Criteria:
- Age ≥18 years
- Histologically confirmed adenocarcinoma of the prostate
- High-risk and/or locally advanced prostate cancer diagnosis defined by:
One of the following criteria is sufficient to define a high-risk and/or locally advanced prostate cancer:
- ISUP grade 4 or 5 on biopsies
- cN1 disease in MRI or PET-Scan
- T3b disease in MRI
If these criteria are not being identified, two of the following criteria are
necessary to define high-risk and/or locally advanced prostate cancer:
- PSA value >20 ng/ml
- ≥ 50% of the core of biopsies need to be positive for adenocarcinoma ISUP grade 3
- T3a disease in MRI
4. No distant metastasis confirmed by imaging (i.e., MRI/CT-Scan and Bone Scintigraphy or
PET-Scan)
5. Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0-1
6. Patient eligible for radical prostatectomy as per the investigator
7. Adequate organ function within 28 days prior to start of treatment determined by the
following central laboratory values:
- Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total
bilirubin less than the upper limit of normal (ULN; note that in subjects with
Gilbert's syndrome, if total bilirubin is >1.5 X ULN, measure direct and indirect
bilirubin. If direct bilirubin is ≤1.5 X ULN, the subject may be eligible);
- Serum creatinine <1.5 mg/dL;
- Platelets ≥75,000/uL, without transfusion and/or growth factors within 1 month
prior to randomization;
- Hemoglobin >12.0 g/dL (7.4 mmol), without transfusion and/or growth factors
within 1 month prior to randomization;
- Adequate renal function: creatinine clearance/eGFR within normal limits to
baseline assessed as per local standard method;
- Normal cardiac function according to local standard by 12-lead Electrocardiogram
(ECG) (complete, standardized 12-lead recording).
8. Patient able to receive darolutamide for up to 9 months as per the investigator
9. Patient able to swallow whole study drug tablets
10. Life expectancy more than 5 years
11. Men should accept (or female partners of men enrolled in the study who are of
childbearing potential or are pregnant) to use an effective contraception during
darolutamide treatment and at least one week after the end of the investigational
product
12. Signed informed consent
13. Patient able to participate and willing to give informed consent prior performance of
any study-related procedures and to comply with the study protocol for the duration of
the study, including undergoing treatment and scheduled visits and examinations
including follow up
14. Patient affiliated to a Social Health Insurance in France.
Exclusion Criteria:
1. Distant metastasis (clinical stage M1). Nodal disease below the iliac bifurcation
(clinical stage N1) is not an exclusion.
2. Pathological finding consistent with small cell, ductal or neuroendocrine carcinoma of
the prostate
3. Prior treatment for prostate cancer
4. Castrated men (Bilateral orchiectomy or other)
5. History of any pelvic radiation
6. Any of the following concurrent illness within 6 months prior to first dose of study
drug: severe or unstable angina, myocardial infarction, symptomatic congestive heart
failure, arterial or venous thromboembolic events (eg, pulmonary embolism,
cerebrovascular accident including transient ischemic attacks), or clinically
significant ventricular arrhythmias or New York Heart Association Class II to IV heart
disease; uncomplicated deep vein thrombosis is not considered exclusionary
7. Uncontrolled hypertension as indicated by a systolic blood pressure (BP) ≥ 160 mmHg or
diastolic BP ≥ 100 mmHg at screening despite medical management. Participants with
hypertension can enroll provided BP is stable and controlled by anti-hypertensive
treatment
8. HIV-positive patient with one or more of the following: Not receiving highly active
antiretroviral therapy; Had a change in antiretroviral therapy within 6 months of the
start of screening; Receiving antiretroviral therapy that may interfere with study
drug; CD4 count <350 at screening; AIDS-defining opportunistic infection within 6
months of start of screening
9. Active or symptomatic viral hepatitis or chronic liver disease; ascites or bleeding
disorders secondary to hepatic dysfunction
10. Gastrointestinal conditions affecting absorption
11. Known or suspected contraindications or hypersensitivity to darolutamide
12. Treatment with strong CYP3A4 inducers and P-gp inducers within 2 weeks or 5
drug-elimination half-lives, whichever is longer, prior to initiation of study drug
13. Major surgery within 28 days before first dose of study treatment
14. Any psychological, familial, geographic or social situation, according to the judgment
of investigator, potentially preventing the provision of informed consent or
compliance to study procedure
15. Patient who has forfeited his/her freedom by administrative or legal award or who is
under legal protection (curatorship and guardianship, protection of justice)
16. Concurrent enrolment in another interventional therapeutic clinical study.