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L-Arginine in Children Having Sickle Cell Disease With Increased Tricuspid Regurgitant Jet Velocity

L-Arginine in Children Having Sickle Cell Disease With Increased Tricuspid Regurgitant Jet Velocity

Recruiting
5-18 years
All
Phase 3
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Overview

This study aims to investigate the possible efficacy and safety of L-Arginine in children having Sickle Cell Disease with increased Tricuspid Regurgitant Jet Velocity

Eligibility

Inclusion Criteria:

  • children having Sickle Cell Disease with increased Tricuspid Regurgitant Jet Velocity
  • age 5-18 years

Exclusion Criteria:

  • Another chronic hemolytic anemia.
  • Patients with documented causes of pulmonary hypertension other than SCD.
  • Allergy to L-arginine.
  • Patients with Asthma.
  • Hepatic dysfunction: serum Alanine Aminotransferase (ALT) > 3X upper value.
  • Renal dysfunction: Creatinine level greater than or equal to 1.2 mg/dl.

Study details
    Sickle Cell Disease

NCT05470998

Tanta University

27 January 2024

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