Overview
This study aims to investigate the possible efficacy and safety of L-Arginine in children having Sickle Cell Disease with increased Tricuspid Regurgitant Jet Velocity
Eligibility
Inclusion Criteria:
- children having Sickle Cell Disease with increased Tricuspid Regurgitant Jet Velocity
- age 5-18 years
Exclusion Criteria:
- Another chronic hemolytic anemia.
- Patients with documented causes of pulmonary hypertension other than SCD.
- Allergy to L-arginine.
- Patients with Asthma.
- Hepatic dysfunction: serum Alanine Aminotransferase (ALT) > 3X upper value.
- Renal dysfunction: Creatinine level greater than or equal to 1.2 mg/dl.