Overview

The purpose of this study is to find out how much tratuzumab deruxtecan (T-DXd) can penetrate the tumor when injected into the body, and whether T-DXd may be an effective treatment for brain cancers that express the HER2 protein.

Eligibility

Inclusion Criteria:

• Adult patients ≥ 18 years of age with one or more brain tumors planned for neurosurgical resection/biopsy
• Pathologically-documented glioblastoma; or
• Metastatic cancer that:
  • Has a history of Her2 expression or activating Her2-mutation
• Her2+ defined as 3+ on IHC
• Her2-low defined as IHC1+ or 2+ and ISH- according to ASCO-CAP 2018 Her2 testing guidelines52
• Her2 mutations must be described to be activating, occur at a known hotspot (e.g. exon 20 insertions, S310, G660, R678, L755, D769, L777), or involve the transmembrane, juxtamembrane or tyrosine kinase domains
• Other untreated brain tumors (and prior radiation, including whole-brain and/or stereotactic radiation) are allowed
• Patients with concomitant leptomeningeal metastasis are eligible provided they have parenchymal brain neoplastic disease requiring resection/biopsy
• Prior treatments:
  • Cohort A: Brain parenchymal metastases in patients with Her2-expressing/ERBB2- activating-mutant cancer with no prior T-DXd exposure (T-DXd naïve)
  • Cohort B: Brain parenchymal metastases in patients with Her2-expressing/ERBB2- activating-mutant cancer with prior T-DXd exposure
  • Cohort C: Recurrent glioblastoma
  • For all cohorts: no limit on prior CNS radiation or systemic therapy, including Her2- targeting antibody therapy (including trastuzumab, pertuzumab, trastuzumab emtansine)
• KPS ≥ 60 Or ECOG < 2
• Life expectancy >12 weeks
• Left ventricular ejection fraction ≥50%
• Adequate bone marrow, renal, hepatic, and coagulation parameters (obtained ≤7 days prior to the first day of study treatment):
  • Absolute neutrophil count (ANC) ≥1.5 × 103/μL (granulocyte-colony stimulating factor administration is not allowed within 1 week prior to C1D1)
  • Platelet count ≥10.0x104/μL. Note: Participants requiring ongoing transfusions or growth factor support to maintain platelet count ≥10.0x104/μL are not eligible. (Platelet transfusion is not allowed within 1 week prior to C1D1)
  • Hemoglobin ≥ 9.0 g/dL. Note: Participants requiring ongoing transfusions or growth factor support to maintain hemoglobin ≥8.0 g/dL are not eligible (> 8 g/dL in gastric cancer / gastroesophageal cancer indications). (Red blood cell transfusion is not allowed within 1 week prior to C1D1)
  • Serum albumin ≥ 2.5 g/dL
  • Creatinine clearance ≥30 mL/min, as calculated using the Cockcroft-Gault equation
  • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤3 × upper limit of normal (ULN) (<5x ULN in participants with liver metastases)
  • Total bilirubin ≤1.5 × ULN) if no liver metastases or <3 × ULN in the presence of documented Gilbert's syndrome (unconjugated hyperbilirubinemia) or liver metastases at baseline
  • International normalized ratio (INR) and activated partial thromboplastin time (aPTT) ≤1.0xULN unless on medication known to reversibly alter INR and/or aPTT
• Evidence of post-menopausal status or negative serum pregnancy test for females of

  childbearing potential who are sexually active with a non-sterilized male partner. For women of childbearing potential, a negative result for serum pregnancy test (test must have a sensitivity of at least 25 mIU/mL) must be available within 7 days of the screening visit and urine beta-human chorionic gonadotropin (β-HCG) pregnancy test prior to each administration of T-DXd.

• Women of childbearing potential are defined as those who are not surgically sterile (i.e.

        underwent bilateral salpingectomy, bilateral oophorectomy, or complete hysterectomy). Women
        will be considered post-menopausal if they have been amenorrheic for 12 months without an
        alternative medical cause.
          -  Female patients of childbearing potential who are sexually active with a
             non-sterilized male partner must use at least one highly effective method of
             contraception, presented in Table 1 from the time of screening and must agree to
             continue using such precautions for 7 months after the last dose of T-DXd. Note:
             estrogen/progesterone is contraindicated in ER+ breast cancer, and in other cancers
             could increase the risk of DVT. Female patients must refrain from breastfeeding while
             on study and for 7 months after the last dose of T-DXd.
          -  Non-sterilized male patients who are sexually active with a female partner of
             childbearing potential must use a condom with spermicide from screening to 4 months
             after the final dose ofT-DXd. Complete heterosexual abstinence for the drug washout
             period is an acceptable contraceptive method if it is in line with the patient's usual
             lifestyle (consideration must be made to the duration of the clinical trial); however,
             periodic or occasional abstinence, the rhythm method, and the withdrawal method are
             not acceptable. It is strongly recommended for the female partners of a male patient
             to also use ≥1 highly effective method of contraception throughout this period, as
             described in Table 1. In addition, male patients should refrain from fathering a
             child, or freezing or donating sperm from the time of enrollment until 4 months after
             the last dose of T-DXd; sperm preservation should be considered prior to enrollment in
             this study.
          -  Female subjects must not donate, or retrieve for their own use, ova from the time of
             enrollment through at least 7 months after the final study drug administration.
             Preservation of ova may be considered prior to enrollment in this study.
          -  Adequate treatment washout period from prior therapies to allow recovery from any
             prior treatment-related toxicities before enrollment in the judgment of the
             Investigator.
        Table 1: Highly effective methods of contraception (<1% failure rate) Non-Hormonal Methods
          -  Total heterosexual abstinence (evaluate in relation to the duration of the clinical
             study and the preferred and usual lifestyle choice of the participant)
          -  Vasectomised sexual partner (if partner is the sole sexual partner of the trial
             participant and that the vasectomised partner has received medical assessment of the
             surgical success)
          -  Bilateral tubal occlusion
          -  Intrauterine device (provided coils are copper banded)
        Hormonal Methods
          -  Combined (estrogen and progestogen containing) hormonal contraception associated with
             inhibition of ovulation (noting relevant contraindications in ER+ breast cancer, and
             risk of DVT in other cancers)
          -  oral
          -  intravaginal
          -  transdermal
          -  Progestogen-only hormonal contraception associated with inhibition of ovulation
          -  oral
          -  injectable
          -  implantable
          -  Intrauterine hormone-releasing system (IUS)
        Exclusion Criteria:
          -  Contraindication or history of allergic reaction to T-DXd
          -  Significant comorbidities as per investigator evaluation
          -  Inability to comply with protocol and/or unwilling or not available for follow up
             assessments or any condition which in the investigator's opinion makes the patient
             unsuitable for study participation
          -  Ferrous or other contraindication to MR imaging
          -  History of myocardial infarction within 6 months before enrollment
          -  History of symptomatic congestive heart failure (New York Heart Association Class II
             to IV)
          -  Corrected QT interval (QTc) prolongation to >470 ms (females) or >450 ms (male) based
             on12-lead electrocardiogram (ECG)
          -  Subjects with troponin levels above ULN at screening (as defined by the manufacturer),
             and without any myocardial related symptoms, should have a cardiologic consultation
             before enrollment to rule out MI
          -  History of (noninfectious) interstitial lung disease (ILD)/pneumonitis that required
             steroids, has current ILD/pneumonitis, or where suspected ILD/pneumonitis can not be
             ruled out by baseline chest CT at Screening.
          -  Lung criteria:
               1. Lung-specific intercurrent clinically significant illnesses including, but not
                  limited to, any underlying pulmonary disorder (e.g. pulmonary emboli within three
                  months of the study enrollment, severe asthma, severe COPD, restrictive lung
                  disease, pleural effusion etc.)
               2. Any autoimmune, connective tissue or inflammatory disorders (e.g. Rheumatoid
                  arthritis, Sjogren's, sarcoidosis etc.) where there is documented, or a suspicion
                  of pulmonary involvement at the time of screening.
               3. Prior pneumonectomy (complete)
          -  Uncontrolled infection requiring IV antibiotics, antivirals, or antifungals
          -  Active primary immunodeficiency, known human immunodeficiency virus (HIV) infection,
             or active hepatitis B or C infection. Patients positive for hepatitis C (HCV) antibody
             are eligible only if polymerase chain reaction is negative for HCV RNA.
          -  Receipt of live, attenuated vaccine (mRNA and replication deficient adenoviral
             vaccines are not considered attenuated live vaccines) within 30 days prior to the
             first dose of trastuzumab deruxtecan. Note: Patients, if enrolled, should not receive
             live vaccine during the study and up to 30 days after the last dose of T-DXd.
          -  Has unresolved toxicities from previous anticancer therapy, defined as toxicities
             (other than alopecia) not yet resolved to Grade ≤ 1 or baseline. Note: Subjects may be
             enrolled with chronic, stable Grade 2 toxicities (defined as no worsening to >Grade 2
             for at least 3 months prior to [randomization/enrollment/Cycle 1 Day 1] and managed
             with standard of care treatment) that the investigator deems related to previous
             anticancer therapy, such as:
               1. Chemotherapy-induced neuropathy
               2. Fatigue
               3. Residual toxicities from prior IO treatment: Grade 1 or Grade 2 endocrinopathies
                  which may include:
             i. Hypothyroidism/hyperthyroidism ii. Type 1 diabetes iii. Hyperglycemia iv. Adrenal
             insufficiency v. Adrenalitis vi. Skin hypopigmentation (vitiligo)
          -  Known allergy or hypersensitivity to study treatment or any of the study drug
             excipients. For patients who are allergic to gadolinium-based agents may receive
             premedication as per institutional protocol or imaged without contrast at the
             discretion of the Principal Investigator; reactions will be managed per standard
             institutional protocol
          -  History of severe hypersensitivity reactions to other monoclonal antibodies
          -  Pregnant or breastfeeding female patients, or patients who are planning to become
             pregnant.
          -  Patients with substance abuse or any other medical conditions such as clinically
             significant cardiac or psychological conditions, that may, in the opinion of the
             investigator, interfere with the subject's participation in the clinical study or
             evaluation of the clinical study results.
          -  Multiple primary malignancies within 3 years, with the exception of:
               1. adequately resected non-melanoma skin cancer
               2. carcinoma in situ of the cervix
               3. Smoldering pre-malignant or malignant conditions with minimal concern for CNS or
                  extracranial progression during treatment such as CLL or MGUS based on the
                  assessment of the treating provider
               4. curatively treated in-situ disease
               5. other solid tumors curatively treated
               6. contralateral breast cancer [patients with metastatic breast cancer].
          -  A pleural effusion, ascites or pericardial effusion that requires drainage, peritoneal
             shunt, or Cell-free and Concentrated Ascites Reinfusion Therapy (CART)