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The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4

The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4

Recruiting
18-70 years
All
Phase N/A
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  • Simplified (AI rewritten)

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Overview

Study goals

  1. Prospective longitudinal data on progression in the natural course of SPG4 in presymptomatic mutation carriers prior to clinical disease onset and in early stages of disease
  2. Biomarkers providing objective measures of disease activity

Eligibility

Inclusion Criteria:

  • First degree relatives (parents, offspring, and sibs) of SPG4 patients or symptomatic individuals with known SPAST mutation
  • Age 18 to 70 years
  • Written, informed consent (patient)

Exclusion Criteria:

  • No known SPAST-mutation within the family
  • Manifest spastic gait (subclinical signs like increased deep tendon reflexes, positive Babinski sign are allowed)
  • Participation in interventional trials

Study details
    Hereditary Spastic Paraplegia
    Hereditary
    Spastic Paraplegia
    Autosomal Dominant

NCT03206190

University Hospital Tuebingen

27 January 2024

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FAQs

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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