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Mapping Auricular Vagus Nerve Circuitry

Mapping Auricular Vagus Nerve Circuitry

Recruiting
18-65 years
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

This study will determine how noninvasive nerve stimulation affects human brain, stomach, and autonomic activity.

Description

Scientific research into the basic mechanisms underlying neuromodulation is relatively recent and incomplete. The purpose of the proposed study is to determine how a form of neuromodulation, transcutaneous electro-accupoint stimulation, which is non-invasive and non-painful, affects human brain, stomach, and autonomic activity. We will accomplish this by integrating whole brain functional MRI (fMRI) methodologies with gastric MRI and physiological monitoring.

This study will comprise 3 functional magnetic resonance imaging (fMRI) brain-gut scans, all while receiving the neuromodulation with varying parameters. Participants will also have their heart rate, breathing, and gastric activity monitored during all visits.

Eligibility

Inclusion Criteria:

  • Adults 18-65
  • Functional dyspepsia

Exclusion Criteria:

  • Any condition contraindicating an fMRI brain scan

Study details
    Healthy

NCT00200889

Massachusetts General Hospital

1 November 2025

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