Overview
To compare the effects of a pneumococcal vaccine called PCV20 when given as a single dose versus a boosted regimen to patients who previously received anti-CD20 therapy as treatment for B cell lymphoma.
Description
Primary Objectives:
--Compare the humoral responses in terms of difference in IgG titers at 1 month from routine single dose PCV20 or a boosted PCV20 regimen in B cell lymphoma survivors who previously received treatment with anti-CD20 therapy.
Secondary Objectives:
- Compare the humoral responses in terms of difference in IgG titers at 3, 6 and12 from routine single dose PCV20 or a boosted PCV20 regimen in B cell lymphoma survivors who previously received treatment with anti-CD20 therapy.
- Estimate the rate of pneumonia (all bacterial pneumonia including pneumococcal pneumonia) within a year from routine single dose PCV20 or a boosted PCV20 regimen in lymphoma survivors who previously received treatment with anti-CD 20 therapy.
- Correlate humoral responses to development of bacterial pneumonia and pneumococcal pneumonia and with severity of this infection in lymphoma survivors within a year of vaccination.
Eligibility
Inclusion Criteria:
- Patients who have a history of non-Hodgkin B-cell lymphoma and whose disease has been in remission for at least 1 year.
- Patients who received any anti-CD20 therapy at any time during their treatment for B-cell lymphoma.
- Patients who are at least 18 years of age.
- Patients who can provide consent; no legal authorized representative will be able to provide consent on a patient's behalf.
Exclusion Criteria:
- Patients who have received cellular therapy, including chimeric antigen receptor T-cell therapy or any type of hematopoietic cell transplantation.
- Patients who have received PCV or pneumococcal polysaccharide vaccine within 5 years of screening for enrollment.
- Patients who are unable to attend follow-up appointments at designated times at MD Anderson.
- Any vulnerable population patient ((children, pregnant women, cognitively impaired adults, or prisoners)