Overview
The objective of this study is to explore the effects of Sirolimus on the underlying molecular alterations of cerebral aneurysms.
Eligibility
Inclusion Criteria:
- Undergoing one of the following procedures at Jackson Memorial Hospital:
- Clipping of an unruptured cerebral artery aneurysm
- Endovascular treatment of unruptured cerebral aneurysms (including those receiving coiling)
- ≥ 18 years of age
- Willing and able to give informed consent
Exclusion Criteria:
- Subjects meeting any of the following criteria will be excluded:
- Dissecting, traumatic, or mycotic brain aneurysm.
- Women who are pregnant, or have a positive urine or blood (β-hCG) pregnancy test.
- Women who are breastfeeding.
- Any clinically significant psychiatric or psychological disease, which would preclude the patient from completing the protocol.
- Patients with known Human Immunodeficiency Virus (HIV) infection or other known immunodeficiency.
- Patient with renal or liver failure
- Interstitial pneumonitis
- History of lymphoma
- History of skin cancer
- Hypersensitivity to sirolimus
- Severe or unstable concomitant condition disease or chronic condition, which in the opinion of the investigator could affect assessment of the safety or efficacy of study intervention.