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Flu-Bu-Mel Based Conditioning Regimen for Patients With Lymphoid Malignancies Undergoing Allo-HSCT

Flu-Bu-Mel Based Conditioning Regimen for Patients With Lymphoid Malignancies Undergoing Allo-HSCT

Recruiting
16-60 years
All
Phase 2
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Overview

In this phase II clinical trial, we evaluate the efficacy and feasibility of conditioning regimen of fludarabine 150mg/m2, busulfan 9.6mg/kg, melphalan 100mg/m2 and etoposide 800mg/m2 in patients with lymphoid malignancies.

Eligibility

Inclusion Criteria:

  • lymphoid malignancies
  • donor available: HLA matched sibling, unrelated donor or haplo-identical related donor.
  • patients with ECOG <3

Exclusion Criteria:

  • inform consent not provided
  • ECOG >=3
  • poor liver function (enzyme >2N or bilirubin >2N)
  • poor renal function (Scr >2N)
  • poor cardiac function (EF <45%)

Study details
    Lymphoid Neoplasm

NCT04897139

Shanghai Jiao Tong University School of Medicine

27 January 2024

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