Overview
In this study, MRI of the lungs of healthy volunteers and participants with cystic fibrosis (stable and participants initiating CFTR modulator treatment) will be performed over a period of 6 months to determine if lung MRI is able detect structural and functional abnormalities/changes in early cystic fibrosis disease. During the 6 month period, 3 study visits will occur. 70 subjects aged 6 and older will participate in this study. Xenon MRI is a non-invasive imaging technique that does not involve x-rays or ionizing radiation. Rather, this imaging method utilizes the same hardware and software principles that are used for conventional proton MRI of patients in a hospital.
Eligibility
Inclusion Criteria:
- Participants must be greater than or equal to 6 years of age
- Informed consent by patient or parent/guardian consent and participant assent when appropriate.
- Able to perform reproducible spirometry and achieve a breath hold duration sufficient for MRI acquisition
Exclusion Criteria:
- Medical instability that would preclude the ability to undergo the required investigations
- FEV1 % predicted < 40%
- Severe claustrophobia
- Does not meet MRI screening criteria
- Cough within the past 3 days prior to study visit
- Usage of oral antibiotics within 3 weeks prior to study visit