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Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD

Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD

Recruiting
6-40 years
All
Phase 4
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Overview

The investigators' goal is to develop neuroimaging biomarkers to predict response to treatment with methylphenidate, which then can be used in the development of novel pharmacological treatments for attention-deficit/hyperactivity disorder (ADHD). The overall objective of this study is to measure the changes in task-related neural activity related to symptoms of ADHD (measured by functional MRI) and brain glutamate levels (measured by magnetic resonance spectroscopy, MRS) after treatment with methylphenidate (MPH). This will be a double-blind crossover of methylphenidate and placebo in adults with ADHD. Participants will complete neuropsychological testing along with fMRI and MRS scans after a single dose of each treatment.

Eligibility

Inclusion Criteria:

  • right handed

Exclusion Criteria:

  • pregnant or breast feeding
  • past or current neurological disorder
  • non-ADHD cause of cognitive impairment
  • uncontrolled medical disorder
  • head trauma with loss of consciousness in the last year or any evidence of functional impairment due to and persisting after head trauma
  • having an adverse reaction to methylphenidate, or other stimulant medication
  • having a contraindication to MRI
  • current smoking

Study details
    ADHD - Combined Type

NCT04781972

Johns Hopkins University

28 May 2024

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