Overview
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with peri-implantitis/peri-implant mucositis and without any cardiovascular disease.
Description
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with peri-implantitis/peri-implant mucositis and without any cardiovascular disease.
90 patients: 30 with peri-implantitis, 30 with peri-implant mucositis and 30 healthy controls and without periodontitis history.
All the patients are assessed for clinical, periodontal, blood and non-invasive ultrasound cardiovascular parameters. Measurements are taken before and after initial periodontal treatment in the peri-implantitis/peri-implant mucositis subjects.
Eligibility
PERI-IMPLANTITIS GROUP
Inclusion Criteria:
• Clinically diagnosed with peri-implantitis according to the EFP/AAP 2017 criteria.
Exclusion Criteria:
- Periodontal treatment, implant surgery, antibiotics, NSAIDs, immunosuppressants during the last 6 months.
- Pregnancy.
- Cardiovascular Diseases.
PERI-IMPLANT MUCOSITIS GROUP
Inclusion Criteria:
• Clinically diagnosed with peri-implant mucositis according to the EFP/AAP 2017 criteria.
Exclusion Criteria:
- Periodontal treatment, implant surgery, antibiotics, NSAIDs, immunosuppressants during the last 6 months.
- Pregnancy.
- Cardiovascular Diseases.
HEALTHY GROUP
Inclusion Criteria:
• Clinically diagnosed with healthy periodontum withouth periodontitis history according to
the EFP/AAP 2017 criteria.
Exclusion Criteria:
- Scaling, antibiotics, NSAIDs, immunosuppressants during the last 6 months.
- Pregnancy.
- Cardiovascular Diseases.