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Neuromodulation of Cardiovascular Risks Associated With Cardiotoxic Chemotherapy

Neuromodulation of Cardiovascular Risks Associated With Cardiotoxic Chemotherapy

Recruiting
18-99 years
All
Phase N/A
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Overview

This study is to determine if low level vagus nerve stimulation will lead to improvement in heart function, heart rate variation, and in the levels of certain chemical markers of inflammation in study participants' blood.

Description

Patients will be asked to use a handheld electrical unit (stimulator) at home to deliver vagus nerve stimulation (low level stimulation) to one ear for a period of 1 hour for 14 days.

Eligibility

Inclusion Criteria:

  • Patients (>18 years) who have received anthracycline-based therapy for breast cancer or lymphoma within the last 30 days
  • A least 1 of following additional criteria:
    • previous chest radiation

      . Age>50

    • type 2 diabetes mellitus
    • hypertension
    • current smoking
    • obesity (BMI ≥ 30)
    • previous myocardial infarction
    • established atherosclerotic heart disease or significant valve disease. chronic kidney disease

Exclusion Criteria:

  • Atrial paced rhythm
  • History of seizure currently on treatment
  • History of vasovagal syncope
  • End stage liver or kidney disease

Study details
    Breast Cancer
    Lymphoma

NCT05921253

University of Oklahoma

1 November 2025

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