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Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department

Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department

Recruiting
18 years and older
All
Phase N/A
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  • Simplified (AI rewritten)

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Overview

The goal of this observational study is to determine the utility of desmosine, D-dimer and aggrecan as early diagnostic biomarkers in aortic dissection. The main questions it aims to answer are:

  • To investigate the plasma levels of selected biomarkers in ED patients with confirmed aortic dissection
  • To study the diagnostic performance of plasma levels of selected biomarkers for aortic dissection
  • To study the association between plasma levels of selected biomarkers and clinical outcomes

Eligibility

Inclusion Criteria:

  • Age ≥ 18 years
  • Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit
  • Confirmed AD
    • the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first
    • The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery.

Exclusion Criteria:

  • Age <18 years old
  • Pregnancy
  • Surgery or stenting performed before recruitment

Study details
    Aortic Dissection

NCT06065306

Chinese University of Hong Kong

2 May 2024

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