Overview
Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).
Description
EXCLAMATORY is a longitudinal observational cohort clinical research study to evaluate the effects of catheter ablation for paroxysmal atrial fibrillation on left atrial and left ventricular performance during exercise, as well as effects on overall exercise capacity
Eligibility
Inclusion Criteria:
- Age ≥18 years
- Diagnosis of paroxysmal AF
- Left ventricular ejection fraction ≥50%
- Scheduled for catheter ablation
- Able to speak, hear, and read English
- Willing and able to provide informed consent
Exclusion Criteria:
- Persistent or permanent AF
- Prior ablation (catheter based or surgical) for AF
- Significant sinus node dysfunction
- Implanted pacemaker or defibrillator
- Contraindication to or inability to complete cardiovascular magnetic resonance study
- Contraindication to or inability to complete exercise testing
- Chronic kidney disease with estimated glomerular filtration rate <30 mL/min/1.73m2
- Severe left ventricular hypertrophy
- Unrelated cardiomyopathy that is expected to limit exercise capacity, including but
not limited to:
- Hypertrophic cardiomyopathy
- Cardiac amyloidosis
- Constrictive pericarditis
- Pulmonary arterial hypertension
- Prior cardiac surgery
- Active pregnancy