Overview
An eczematous reaction is an inflammatory intolerance response of the skin. In acute phase the reaction is characterized by erythema and blistering while in the chronic phase it presents as dryness, itchiness and lichenification. Irritative contact dermatitis describes these patterns of reaction in response to toxicity of chemicals on the skin cells, which trigger inflammation by activation of the innate immune system.
Description
An eczematous reaction is an inflammatory intolerance response of the skin. In acute phase the reaction is characterized by erythema and blistering while in the chronic phase it presents as dryness, itchiness and lichenification. Irritative contact dermatitis describes these patterns of reaction in response to toxicity of chemicals on the skin cells, which trigger inflammation by activation of the innate immune system. Therefore, the aim of this study was to see if omega cream, as proposed by its mechanism of action, could improve SLS induced contact dermatitis.
Eligibility
Inclusion Criteria:
- healthy volunteers who gave written informed consent
Exclusion Criteria:
- · skin cancer
- skin disease
- skin damage on measurement sites
- use of corticosteroids, antihistamines and immunomodulators a month prior the inclusion and during the trial
- use of drugs that may cause photosensitivity
- use of emollients three days prior the inclusion in the trial
- non-adherence to the trial protocol
- exposure to artificial and excessive natural ultraviolet (UV) radiation
- pregnancy and lactation
- history of vitiligo, melasma and other pigmentation and photosensitivity disorders
- immunosuppression
- allergic or irritant reactions to the constituents of the cream