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Low Energy Availability and Pituitary Function (LEAP Study)

Low Energy Availability and Pituitary Function (LEAP Study)

Non Recruiting
18-30 years
Female
Phase N/A

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Overview

The purpose of this study is to learn more about reproductive hormones and if they change in response to 5-days eating an individualized, standardized diet at two levels: energy balance and low energy intake.

Eligibility

Inclusion Criteria:

  • Female
  • Age 18-30
  • Body mass index between 18.5-24.9 OR 30-45
  • Have regular menstrual cycles between 18-40 days over the past 6 months
  • Weight stable (not gained or lost 5kg) in the past 3 months

Exclusion Criteria:

  • Using hormonal birth control currently or within the past three months
  • Polycystic ovary syndrome (current or past diagnosis)
  • Pregnant, lactating, planning to become pregnant in next 6 months
  • Engaging in regular intentional aerobic exercise
  • Significant medical issues (e.g.,cardiovascular disease or diabetes)

Study details
    Hypogonadotropic Hypogonadism

NCT05808647

University of Colorado, Denver

20 August 2025

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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