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Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy For Locally Advanced Breast Cancer

Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy For Locally Advanced Breast Cancer

Recruiting
18 years and older
Female
Phase N/A
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  • Simplified (AI rewritten)

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Overview

This study is being done to help the investigators determine how accurate the sentinel lymph node biopsy (SLNB) procedure is in identifying residual cancer cells after neoadjuvant chemotherapy in patients presenting with locally advanced breast cancer.

Eligibility

Inclusion Criteria:

  • Female patients over 18 years of age with biopsy-proven breast cancer
  • Patients presenting with locally advanced disease in the breast (cT4) and/or in the nodes (cN2/N3) as assessed by clinical exam and imaging
  • Patients presenting to surgery clinic after receipt of NAC at outside hospital with documentation of cT4 or cN2/3 disease on initial outside physical exam and imaging studies
  • Patients receiving NAC and having a nodal complete clinical response as assessed by physical exam

Exclusion Criteria:

  • Patients with a prior history of ipsilateral breast cancer
  • Pregnant patients
  • Patients with persistent palpable axillary nodes after NAC, as assessed by physical exam
  • Patients not consenting to ALND

Study details
    Breast Cancer
    Locally Advanced Breast Cancer

NCT03255577

Memorial Sloan Kettering Cancer Center

27 January 2024

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