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L-carnitine in Modulating Pain and Inflammation in Rheumatoid Arthritis

L-carnitine in Modulating Pain and Inflammation in Rheumatoid Arthritis

Recruiting
18-70 years
All
Phase 3
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Overview

This study aims at evaluating the possible efficacy and safety of L-carnitine in rheumatoid arthritis via targeting Jak/STAT pathway and TGF-β1

Eligibility

Inclusion Criteria:

  • Patients with active rheumatoid arthritis (not in remission) according to American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) 2010 criteria (9) i.e., 28 joints disease activity score (DAS-28) >2.6.
  • Patients receive the conventional DMARDs
  • Both sexes.
  • Age range between 18 and 70 years old.

Exclusion Criteria:

  • Patients with heart disease (congestive heart failure, arrhythmia, hypertension, ischemic heart diseases), diabetes, active infection, other illness except rheumatoid arthritis.
  • Patients with renal and hepatic dysfunction.
  • Patients receiving biological DMARDs.
  • Patients receiving oral prednisolone greater than 15 mg/day.
  • Patients with hypersensitivity to study medications.
  • Patients using antioxidants.
  • Pregnant and lactating females.

Study details
    Rheumatoid Arthritis

NCT05792527

Tanta University

27 January 2024

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