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Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.

Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.

Recruiting
18-99 years
All
Phase N/A
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Overview

This study aims to observe inflammatory biomarkers and their trend over the history of the disease in patients suffering from MPN Ph negative; it also wants to identify any correlations between the aforementioned biomarkers and disease outcomes, considering first of all the occurrence of thrombo-haemorrhagic events and the evolution in the accelerated / blast phase of the disease, shedding light on new tools that can potentially guarantee a prompt and better risk stratification

Eligibility

Inclusion Criteria:

  • Age ≥ 18 years at the time of diagnosis of MPN Ph negative
  • Diagnosis of PV, ET, PMF or post PV and post ET MF, according to current WHO or IWG-MRT criteria (diagnosis since 2000)
  • Obtaining informed consent

Exclusion Criteria:

  • Life expectancy of less than 6 months
  • Accelerated phase myelofibrosis or MPN with signs of leukemic evolution

Study details
    Myeloproliferative Disease
    Inflammatory Markers

NCT05553873

University of Milano Bicocca

27 January 2024

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