Overview

This is a prospective, open, single-center clinical study of renal preservation therapy in high-risk upper urinary tract urothelial carcinoma patients . The study was conducted in accordance with the Good Practice for Quality Control of Clinical Trials for Pharmaceutical Products (GCP). Approximately 20 subjects will be enrolled to evaluate the efficacy and safety of RC48 (2.0 mg/kg intravenously every 3 weeks) combined with Tislelizumab (200mg intravenously every 3 weeks).

Eligibility

Inclusion Criteria:

        ECOG: 0~2; HER-2 IHC 1+~3+; Subjects underwent cystoscopic/ureteroscopic biopsy,
        exfoliation cytology, and CT/MRI diagnosis; Patients were judged to be high-risk urothelial
        carcinoma of the upper urinary tract (meeting any of the following risk factors:
        hydronephrosis, tumor diameter ≥2cm, high-grade, multiple tumors in cytology, previous
        history of radical cystectomy for high-grade bladder cancer, biopsy pathology with other
        tissue components); High-risk UTUC(excluding low-risk UTUC) N0(N1 can be used for patients
        in the middle and lower ureter segment) M0; Patients with indications of absolute or
        relative renal protection (only kidney, renal insufficiency: eGFR < 60 ml/min) Have the
        desire to protect the kidney; There is no indication of absolute or relative kidney
        preservation, but patients have a strong desire to preserve kidney.
        Has and agrees to provide cystoscopic/ureteroscopic biopsy tissue specimens and to reserve
        pre-treatment blood, Urine and biopsied biological samples; Predicted survival ≥3 months;
        Major organ function is normal (14 days prior to enrollment) International Normalized ratio
        (INR), activated partial thromboplastin time (aPTT) : ≤1.5× ULN (This criterion only
        applies to patients who are not receiving anticoagulant therapy; Patients receiving
        anticoagulant therapy should keep anticoagulants within therapeutic limits); Did not
        receive systemic corticosteroid medication within 4 weeks prior to treatment; Fertile men
        or women who are at risk of becoming pregnant must use a highly effective contraceptive
        method during the trial (such as oral contraceptives, intrauterine devices, controlled
        sexual desire or barrier contraception combined with spermicide) and continue using
        contraception for 12 months after the end of treatment; The subjects voluntarily joined the
        study, signed the informed consent, had good compliance, and cooperated with follow-up.
        Exclusion Criteria:
        Previously received anti-PD-1, anti-PD-L1, anti-PD-L2 therapy, including adjuvant therapy
        stage; Known allergy to recombinant humanized anti-PD-1 monoclonal antibody drugs and their
        components; Had received other antitumor therapy (including corticosteroid therapy,
        immunotherapy) or participated in other clinical studies within 4 weeks prior to the study
        treatment, or had not recovered from the previous toxicity (except for 2 degrees of hair
        loss and 1 degree of neurotoxicity); Pregnant or lactating women; Positive HIV test result;
        People with active hepatitis B or C HBsAg or HBcAb positive patients also detected HBV DNA
        copy number positive (quantitative detection limit is 500IU/ml, or reach the positive value
        of the study center); Screening studies of such patients must test for HBV DNA; Patients
        who tested positive for HCV antibodies were enrolled in this study only if the PCR results
        of HCV RNA were negative.
        A clear history of active tuberculosis; Have active autoimmune diseases that have required
        systemic treatment within the past 2 years (e.g., with disease-regulating drugs,
        corticosteroids, or immunosuppressive drugs) that allow for relevant replacement therapy
        (e.g., thyroxine, pancreatic hormone, or physiologic corticosteroid replacement therapy for
        renal or pituitary insufficiency); Other serious, uncontrolled concomitant diseases that
        may affect protocol adherence or interfere with interpretation of results, These include
        active opportunistic or progressive (severe) infections, uncontrolled diabetes,
        cardiovascular disease (heart failure of Grade Ⅲ or Ⅳ as defined by the New York Heart
        Association scale, heart block above grade Ⅱ, myocardial infarction within the past 6
        months, unstable arrhythmia or unstable angina, cerebral infarction within 3 months, etc.)
        Or pulmonary disease (history of interstitial pneumonia, obstructive pulmonary disease, and
        symptomatic bronchospasm); Received live vaccine within 4 weeks prior to the start of
        treatment; Have previously received allogeneic hematopoietic stem cell transplantation or
        solid organ transplantation; Major surgical procedures (excluding diagnostic surgery)
        within 4 weeks prior to the start of treatment; Those who have a history of psychotropic
        drug abuse and cannot abstain or have a history of mental disorders; A large amount of
        pleural effusion or ascites accompanied by clinical symptoms or requiring symptomatic
        treatment; Have had other unhealed malignancies in the past 5 years, excluding those that
        are apparently cured or curable, such as basal or squamous cell skin cancer, localized
        low-risk prostate cancer, carcinoma in situ of the cervix or carcinoma in situ of the
        breast; Remarks: Patients with localized low-risk prostate cancer (defined as stage ≤T2a,
        Gleason score ≤6, and PSA≤10ng/mL at the time of prostate cancer diagnosis (as measured)
        who had received radical therapy and had no biochemical recurrence of prostate specific
        antigen (PSA) were eligible to participate in this study); Bladder cancer (MIBC) Other
        severe, acute, or chronic medical or psychiatric conditions or laboratory abnormalities
        that, according to the investigator, may increase the risks associated with study
        participation or may interfere with the interpretation of the study results.