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Antibiotic Dosing in Pediatric Intensive Care

Antibiotic Dosing in Pediatric Intensive Care

Recruiting
1-16 years
All
Phase N/A
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  • Simplified (AI rewritten)

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Overview

Pharmacokinetics of antibiotics in critically ill neonates, infants and children

Eligibility

Inclusion Criteria:

  • patients admitted to the pediatric intensive care unit
  • patient age/weight : 1,8 kg-15 years
  • patient receiving antibiotic treatment (piperacillin-tazobactam, amoxicillin-clavulanate, vancomycin, teicoplanin, meropenem, ciprofloxacin, amikacin) via intermittent infusion regimen or continuous infusion according to institutional treatment guidelines
  • intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred)

Exclusion Criteria:

  • no catheter in place for blood sampling
  • absence of parental/patient consent
  • known hypersensitivity to beta-lactam antibiotics, glycopeptides, fluoroquinolones, aminoglycosides
  • extracorporeal circuit (haemodialysis, ECMO, peritoneal dialysis )

Study details
    Pharmacokinetics
    Amoxicillin-clavulanate
    Piperacillin-tazobactam
    Vancomycin
    Teicoplanin
    Meropenem
    Ciprofloxacin
    Amikacin

NCT02456974

University Hospital, Ghent

27 January 2024

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