Overview
This study evaluates the effect and feasibility of expanding the target population in the Danish cervical cancer screening program to include women aged 65 to 69 years. The study also evaluates if HPV self-sampling constitutes an appropriate screening method among older women.
Description
The study is a nationwide population-based prospective cohort study embedded in the routine cervical cancer screening program in the Central Denmark Region. The study includes all 65 to 69 years old Danish women with no record of a cervical cytology sample or screening invitation within the last five years. Furthermore, the women are not registered as ineligible for screening, eg due hysterectomy. Eligible women residing in the Central Denmark Region are allocated to the intervention group (n=20,000), while women residing in the other four Danish regions are allocated to the control group receiving standard care (n=71,500), which for this group is low-level opportunistic screening at the general practitioner (GP). The intervention group are invited for HPV-based screening by the GP or to request a self-sampling kit.
Eligibility
Inclusion Criteria:
- 65 to 69 years;
- Resident in Denmark
- No record of a cervical cytology or screening invitation in the past 5 years
- Not registered as ineligible for screening
Exclusion Criteria:
- Death
- Migration to or from Denmark
- Moving to or from the CDR
- Residing in the CDR, but having GP in another region
- A record of hysterectomy