Overview

The purpose of this study is to assess the safety, tolerability and preliminary effectiveness of CC-92480 (BMS-986348) in novel therapeutic combinations for the treatment of Relapsed or Refractory Multiple Myeloma (RRMM).

Eligibility

Inclusion Criteria:

• Relapsed or refractory multiple myeloma (MM) and must:
  1. have documented disease progression during or after their last myeloma therapy
  2. be refractory to, intolerant to, or not a candidate for available, established therapies known to provide clinical benefit in MM
• Must have measurable disease
• Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1
• Agree to follow the CC-92480 Pregnancy Prevention Plan (PPP)

Exclusion Criteria:

• Known active or history of central nervous system (CNS) involvement of MM
• Plasma cell leukemia; Waldenstrom's macroglobulinemia; polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome; or clinically significant light-chain amyloidosis.
• Impaired cardiac function or clinically significant cardiac disease
• Previous SARS-CoV-2 infection within 14 days for asymptomatic or mild symptomatic infections or 28 days for severe/critical illness prior to Cycle 1 Day 1 (C1D1)
• For Part 1: received prior therapy with CC-92480
• For Part 2: received prior therapy with CC-92480, tazemetostat, BMS-986158, or trametinib
• Previously received allogeneic stem-cell transplant at any time or received autologous stem-cell transplant within 12 weeks of initiating study treatment
• Received any of the following within 14 days prior to initiating study treatment:
  1. Plasmapheresis
  2. Major surgery
  3. Radiation therapy other than local therapy for myeloma associated bone lesions
  4. Use of any systemic anti-myeloma drug therapy
• Used any investigational agents within 28 days or 5 half-lives (whichever is shorter)

  prior to initiating study treatment

• COVID-19 vaccine within 14 days prior to C1D1

Other protocol-defined inclusion/exclusion criteria apply