Overview
The goal of the study is to validate the ability of the Epigenetic Sperm Quality Test (SpermQT) to assess a man's sperm quality and corresponding success of infertility treatments.
Description
This prospective study will consist of analyzing a man's semen sample to determine the patient's SpermQT score and following the success of each fertility treatment to produce a pregnancy and live birth. Physicians and patients will be blinded to SpermQT results.
Eligibility
Inclusion Criteria:
- The subjects have been recommended to pursue IUI, or they have recently completed an IUI (regardless of outcome)
- Male partner is under 45 years of age
- Female partner is under 38 years of age
- The total motile sperm count from the raw semen analysis must be greater than or equal to 10 million
Exclusion Criteria:
- The female or male partner have a BMI equal to or greater than 40
- The male partner has undergone male testosterone replacement therapy in the last 6 months
- Either the female or male partner have a history of recurrent pregnancy loss, defined as 2 or more consecutive clinical/ultrasound pregnancy losses
- There are any known factors contributing to female factor infertility, such as but not limited to:
- Severe Endometriosis (stage 3 or higher, endometrioma on ovaries)
- Multiple uterine fibroids 5cm or larger
- Severe Asherman's Syndrome
- Severe Mullerian anomaly
- Lack of tubal patency in at least one fallopian tubes