Overview
The study objectives are to improve the treatment of LACC patients and to increase knowledge of the potential benefit of the plan-of-the-day concept on side effects during and after radiotherapy.
Eligibility
Inclusion Criteria:
- Histologically confirmed cervical cancer eligible for definitve radiochemotherapy
- FIGO stage IB1-IVa
- Over 18 years
- Speaks and understands Norwegian or English.
- ECOG 0-2
- Histology: Squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma
- Ability to understand and fill in patient questionnaires, and willing to sign a written informed consent
- Large movers (LM), fundus movement ≥2,5 cm.
Exclusion Criteria:
- Evidence of distant metastasis. Suspicious paraaortic lymphnodes below the renal vessels is allowed if they are covered by the radiation field
- Patients with previous surgery for their cervical cancer
- Uncontrolled intercurrent somatic illness.
- Psychiatric illness /social situations limiting study compliance
- Prior radiotherapy to the pelvis
- Patients who are pregnant or breastfeeding is excluded due to risk of teratogenic and abortifacient effects of radiotherapy and cisplatin, and the potential risk of adverse effect of nursing infants
- Patients under current treatment for other invasive s except non-melanoma skin cancers
- Nephrostomy
- Patients with inflammatory bowel disease