Overview
it is a prospective longitudinal observational study, aiming to to identify clinical, and biochemical baseline predictors of motor and non-motor PD progression in sample of Egyptian patients. it measures the baseline motor, non-motor, biochemical and imaging characteristics at enrollment and its relation to PD progression over 3 years
Description
it is a prospective longitudinal observational study, aiming to to identify clinical, and biochemical baseline predictors of motor and non-motor PD progression in sample of Egyptian patients. it measures the baseline motor, non-motor, biochemical and imaging characteristics at enrollment and its relation to PD progression over 3 years.
The aim of this study is to identify clinical, and biochemical baseline predictors of motor and non-motor PD progression in sample of Egyptian patients.
- Methods
Assessment:-
Time • During the 2 years recruitment of patients from 2019 to 2021, the assessment will be at base line (first clinic visit), after 1yr, and after 2yrs.
Patients will be subjected to:
Clinical assessment:
- At base line, Patients will complete an extensive clinical evaluation, including:
- Comprehensive medical history and neurological examination.
- Demographic information (sex, age, education level, and occupation), as well as clinical characteristics of them (age at onset, duration of illness, received medications and doses).
- Motor assessment; Movement Disorder Society (MDS) -Unified Parkinson's Disease Rating Scale (MDS-UPDRS) he motor portion (Part III) during OFF and ON states, Hoehn & Yahr, and Schwab & England scales.
- Gait assessment, Gait will be assessed by:
Freezing of gait questionnaire Berg balance scale 10 m walk test Timed up and go test
Physical activity scale for elderly (PASE). Cognitive assessment; MOCA, MMSE. Cognitive assessment : during On state.
- All patients will be evaluated for global cognitive assessment by:
- Mini Mental State Examination (MMSE)Arabic version
- Montreal Cognitive Assessment (MoCA) Arabic version
- The standard battery included cognitive tests in the following domains: visuospatial skills, language, attention, executive functioning, and memory.
- Visuospatial skills will be assessed by clock drawing test and copy the intersecting pentagons of Addenbrooke's test (Arabic version)
- Language will be examined by Language similarity & language subset of Addenbrooke's test (Arabic version)
- Attention will be evaluated by forward &backward digit span tests and by the number of seconds needed to sequence numbers using a pencil (Trail making test A)
- For the evaluation of memory, participants will complete Wechsler memory subset, and investigators also will use their three-item recall from the MMSE.
- Executive functions will be measured by Wisconsin card sorting test and also Semantic verbal fluency test .
The non-motor symptoms scales (NMSS). Beck depression inventory (BDI). The Arabic version of The Parkinson's Disease Questionnaire (PDQ-39). Lab investigations MRI brain or CT brain . Serum alpha -Synuclein auto antibodies
All the following will be done at baseline, after 1 year, and after 2 year except, MRI brain and serum alpha-synuclein (only at baseline ).
This study will be approved from the ethical committee of Faculty of Medicine, Ain -Shams University.
Eligibility
Inclusion Criteria:
- • All are Arabic-speaking individuals diagnosed with PD by a movement disorder
neurologist based on the UK bank criteria for idiopathic Parkinson's disease.
- An oral informed consent will be taken from the cases before they participate in the study.
Exclusion Criteria:
- Patients with red flag for being diagnosed with IPD and indicating secondary eg:
vascular, Neuroleptics or atypical parkinsonism , progressive supranuclear palsy,
multiple system atrophy, corticobasal degeneration syndrome, Lewy body dementia
- Patients with with other comorbid chronic diseases
- PD patients who refused or could not complete questionnaires.