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Rehabilitation in Safety-net Environments (RISE) to Improve Outcomes in Vulnerable Patients With COPD

Rehabilitation in Safety-net Environments (RISE) to Improve Outcomes in Vulnerable Patients With COPD

Recruiting
40-90 years
All
Phase N/A

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Overview

Chronic obstructive pulmonary disease (COPD), one of the leading causes of death in the US, disproportionately affects low socioeconomic communities. While few interventions effectively modify the course of COPD and improve outcomes, pulmonary rehabilitation is the one notable exception. However, implementation of this resource-intensive program in real-life settings, and in particular, for underserved communities, has proven to be challenging. Safety-net centers that serve primarily under-insured populations lack financial resources to provide pulmonary rehabilitation.

The 10-week COPD Wellness and Plus+ Program directly addresses this gap, and yet, programs like these do not automatically lead to improved outcomes, which leads to the implementation of a Health Advocates program to address participant's social needs and barriers to healthcare.

Description

The proposed study will directly test the benefit of the 10-week COPD Wellness and Plus+ Program relative to usual care and estimate the added benefit of the HA in COPD Wellness Plus+ to COPD Wellness alone in a three-arm, randomized waitlist-controlled trial conducted in three geographically isolated urban primary care sites that provide care for some of the most socially vulnerable patient populations with COPD. In this Type 1 effectiveness-implementation hybrid design, the investigators aim to 1) determine the effectiveness of COPD Wellness and Plus+ to improve functional and symptom outcomes; and, using a mixed-methods approach 2) to evaluate the implementation of COPD Wellness and Plus+ across study sites applying the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) and Consolidated Framework for Implementation Research (CFIR) frameworks to identify additional barriers and enablers of intervention implementation and patient acceptance and adherence.

Eligibility

Inclusion Criteria:

  • Provision of signed and dated informed consent form
  • Willingness to participate in the COPD Wellness program
  • 40 to 90 years old
  • English or Spanish speaking
  • Physician-diagnosed COPD
  • Spirometry-confirmed FEV1/FVC ratio <= 0.7 and FEV1% predicted <80% based on GLI-O prediction equation
  • COPD Assessment Test ≥ 10 or history of 1+ exacerbation requiring hospitalization or 2+ outpatient exacerbations requiring steroid therapy
  • Currently prescribed COPD medication(s)
  • Ability to exercise with lower extremities
  • No COPD exacerbations for ≥ 6 weeks
  • Currently receiving care within SFHN
    • Note: Forced expiratory volume in the first second (FEV1); Forced vital capacity (FVC)

Exclusion Criteria:

  • Pregnancy
  • Dementia, cognitive impairment, or symptomatic psychiatric illness that would impair them from participating
  • Unstable cardiovascular disease (includes recent [<6 months] myocardial infarction or pulmonary embolism, uncontrolled arrhythmia, poorly controlled heart failure)
  • Other severe co-morbidity which means exercise is contraindicated (screened by Registered Nurse in consultation with Pulmonologist)
  • Transmittable pulmonary infection (tuberculosis, COVID19)
  • Participated in pulmonary rehabilitation in the past 12-months
  • COPD exacerbation in the past 6 weeks
  • Activities restrictions that limit one's ability to engage in moderate physical activity
  • Other diagnosis or condition that carry a prognosis of death within the next year

Study details
    COPD (Chronic Obstructive Pulmonary Disease)

NCT05572632

University of California, San Francisco

29 January 2024

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