Overview

The SIOPEN BIOPORTAL is a prospective non-therapeutic multi-centre international study aimed at developing an international Registry linked to a Virtual Biobank for all the patients with peripheral neuroblastic tumor within countries of the SIOPEN network. The overall aim of this study is to provide a GDPR-compliant framework to collect basic clinical annotations, biological and genetic features and information about the location on biospecimens for all the patients with a peripheral neuroblastic tumor including neuroblastoma, ganglioneuroblastoma and ganglioneuroma in the SIOPEN network.

This study will support data and sample management and intensify cross-borders data and sample sharing fostering translational and clinical research. The post-hoc hypothesis formulated based on the data generated in this study will be used as statistical basis for future precision medicine programs based on improved biological characterization, patient stratification and therapeutic management.

Eligibility

Inclusion Criteria:

        I-1. Patients with PNT: ganglioneuroma or ganglioneuroblastoma or neuroblastoma, I-2. At
        the time of initial diagnosis of neuroblastic tumour, or at relapse/progression if not yet
        registered I-3. Written patient informed consent, or parents or legal representative
        written informed consent and assent of the child, adolescent or young adult
        Non-Inclusion Criteria:
        R-1. (Adult) Patients with olfactory neuroblastoma R-2. Central nervous system (CNS)
        neuroblastoma (as per the WHO classification)