Overview
A six month randomized controlled intervention with an exogenous ketone salt (EKS) supplement in mild cognitive impairment. Participants will receive 15 g of the supplement twice daily (equivalent to 24 g/day of EKS). Outcomes: brain energy metabolism, cognition, plasma biomarkers, brain imaging (volumetric, functional, structural) and quality of life will be analyzed before and after the intervention.
Eligibility
Inclusion Criteria:
- The participant must answer Yes to the question ''Do you think your memory is not as good as it was?''
- Have a MoCA Score between 20/30 and 26/30
- Have a QAF score of less than 9/30
- Understand, read and talk French
- Having good visual and hearing acuity
Exclusion Criteria:
- Major cognitive decline or neurodegenerative disease.
- Already consuming a daily medium chain triglyceride or ketone supplement.
- Soy, milk, gluten or allergy to the study product
- Controlled or uncontrolled diabetes
- Uncontrolled chronic disease
- Vitamin B12 deficit
- Clinical anomaly in the blood chemistry profile
- QSP-9 score over 19/27
- Taking an anti-cholinergic drugs
- Recent change in medication
- Active cancer in the last 2 years
- General anesthesia in the last 6 months
- history of alcohol abuse or dependence in the last 2 years
- Participation in other interventional or PET research project
- Unable to undergo an MRI or PET scan
- History of kidney stones or hypercalcemia
- History of cardiovascular events or insufficiency
- Renal failure and / or creatinine <58 umol or> 110 umol for men and <46 umol or> 92 umol for women or if the GFR (glomerular filtration rate) <60 ml / min / 1.73 m2
- Chronic disease of the digestive system or intestinal malabsorption (celiac disease, chronic pancreatitis, Crohn's disease, etc.)
- Body mass index <20 or voluntary weight loss of more than 5% in the last 6 months.