Overview
This 6-month, naturalistic cohort study examines male and female inpatients aged 18 to 75 years i) with any form of unipolar depressive episode (cohort 1); ii) clinical diagnosis of a moderate or severe unipolar depressive episode and suicidal tendencies who agree to participate in a prospective study (cohort 2); and moderate or severe unipolar depressive episodes validated by research interviews and and suicidal tendencies that persist for at least 48 hours after admission who are followed up for 6 months (cohort 3).
Description
Epidemiological cross-sectional study in over 3000 inpatients with a clinical diagnosis of major depressive disorder, validation of the clinical diagnosis in 520 patients, and prospective naturalistic 6-month follow-up study of 260 adults with a research interview-confirmed major depressive disorder, with data collection at the following points: at T0 = time of hospitalization (epidemiological study population 1 with data from clinical routine practice), at time T1 of baseline survey in patients with persistent suicidal tendencies, i.e. at least 48 hours after T0 (study population 2 as a subgroup of study population 1, with study information and consent), and in study population 3 (subgroup of study population 2, with study information and consent) at the time of discharge (T2), 3 months after admission to hospital (T3/ by telephone) and 6 months after inpatient admission (T4).
The aim of the study is to characterize the remission or recurrence of suicidal symptoms in the context of a depressive episode. It is expected that the results will help to improve the understanding of the disease process and the further development of effective intervention options.
Eligibility
Inclusion Criteria:
For Population 1
1.any form of unipolar depressive episode
For Population 2
- clinical diagnosis of a moderate or severe unipolar depressive episode
- clinically diagnosed suicidal tendencies that persist for at least 48 hours after admission to hospital
- Written consent to participate in the study
For Population 3
- Diagnosis of a moderate or severe unipolar depressive disorder through the structured research interview "Mini International Neuropsychiatric Interview" (M.I.N.I.)
- Suicidality with a value > / = 1 for item 2 (passive suicidality) OR item 3 (active suicidality) based on the research interview "Sheehan Suicidality Tracking Scale" (S-STS)
- Written consent to participate in the study
Exclusion Criteria:
- Patients younger than 18 years or older than 75 years
- No clinical diagnosis of a depressive episode
- Depressive episode in the context of a bipolar disorder- secondary depression as a result of physical illness or substance use
- severe physical symptoms of disease that make participation in the study impossible
- Pregnancy
- not being able to understand the study processes
- incapable of giving informed consent
- no authorization to give consent due to (limited) incapacity