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Improving Infant Hydrocephalus Outcomes in Uganda

Improving Infant Hydrocephalus Outcomes in Uganda

Recruiting
1-180 years
All
Phase N/A
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Overview

Neonatal postinfectious hydrocephalus (PIH) is a major public health problem in East Africa.The standard treatment has long been placement of a ventriculoperitoneal shunt (VPS) but these devices require life-long maintenance and nearly all fail multiple times. Endoscopic Third Ventriculostomy (ETV) with Choroid Plexus Cauterization (ETV/CPC) is an alternate treatment to give patients a shunt-free life. In this study, the investigators aim to optimize the metrics of evaluation as quantitative prognostic indicators of treatment response and long term outcomes.

Eligibility

Inclusion Criteria:

  • Infants less than 180 days (six months) old
  • Symptomatic hydrocephalus characterized by abnormal rate of head growth, full anterior fontanel, ventriculomegaly
  • A parent or a guardian qualified by Ugandan law to give informed consent
  • Patients from Eastern, Central and Northern districts of Uganda, and in geographic proximity to CURE hospital will be eligible

Exclusion Criteria:

  • Age greater than six months
  • No evidence of progressive hydrocephalus
  • Patients outside of the districts specified in the inclusion criteria

Study details
    Hydrocephalus

NCT03650101

Boston Children's Hospital

27 January 2024

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