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The Molecular Pathogenesis Study of Cataract

The Molecular Pathogenesis Study of Cataract

Recruiting
18-90 years
All
Phase N/A
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  • Simplified (AI rewritten)

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Overview

To study the molecular pathogenesis of cataract and explore possible treatments，anterior lens capsules were collected from cataract patients

Description

Anterior lens capsules were collected from the patients with DC and ARC, and transparent crystals of cadaveric eyes. M6A epitranscriptomic microarray was performed to investigate the altered m6A modifications and determine the differentially expressed mRNAs. The potential role of dysregulated m6A modification levels was predicted through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. Real-time polymerase chain reaction was performed to identify the dysregulated expression of RNA methyltransferases, demethylases, and readers.

Eligibility

Inclusion Criteria:

  • diabetic cataract
  • underwent cataract surgery

Exclusion Criteria:

  • Combined with other eye diseases
  • underwent other eye surgery

Study details
    Cataract
    Pathogenesis

NCT05682001

Eye & ENT Hospital of Fudan University

27 January 2024

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