Overview
Chronic obstructive pulmonary disease (COPD) is a worldwide chronic inflammatory disease of the airways linked to environmental exposure. The chronic course of COPD is often interrupted by acute exacerbations which have a major impact on the morbidity and mortality of COPD patients. A bacterial etiology for these exacerbations is common (almost 50%). Moreover, airway bacterial colonization linked to an increased susceptibility is observed in COPD patients. Effective Th17 immune response is needed to develop a good response against bacteria. Thus, this study aims to demonstrate that there is a defective IL-17/ IL-22 response to bacteria in COPD leading to airway bacterial colonization and infection.
Eligibility
Inclusion Criteria:
- Diagnosed COPD according GOLD guidelines
- Current or ex-smoker (at least 10 pack-years)
- Hospitalized for COPD exacerbation
Exclusion Criteria:
- Asthma or Cystic fibrosis
- No other chronic lung disease
- Solid Tumor unhealed or not considered in remission
- Inhaled drug consumption
- Women of childbearing potential without effective contraception
- Pregnant or breastfeeding women
- Incapable of consent
- Lack of social security coverage