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Research on Optimal Diagnosis and Treatment of Cardiorenal Syndrome

Research on Optimal Diagnosis and Treatment of Cardiorenal Syndrome

Recruiting
18 years and older
All
Phase N/A

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Overview

To estimate the characteristics, pathogenesis, risk factors and intervention measures for different stages of heart and kidney diseases, and to optimize the curative effects of different treatment schemes

Description

Cardiorenal syndrome is a clinical syndrome caused by acute or chronic injury of one of the heart and kidney resulting to acute or chronic dysfunction of the other organ. In recent years, the morbidity of cardiorenal syndrome has increased rapidly in China. Its condition is complex and difficult to treat. Due to the lack of studies specifically targeting the cardiorenal syndrome population, there is no systematic in-depth understanding of the pathogenesis and risk factors of this kind of disease. In clinic, the course of various types of cardiorenal syndrome is complex and difficult to be summarized into a specific type. Therefore, we intend to conduct a clinical systematic observation and research on such patients so as to optimize a more reasonable treatment scheme.

Eligibility

Inclusion Criteria:

        Patients meet the diagnosis of various types of cardiorenal syndrome according to the
        classification standards of various types formulated by KDIGO and ADQI expert consensus.
        Different syndromes were identified and classified into five subtypes. Acute CRS (type 1):
        acute worsening of heart function (AHF-ACS) leading to kidney injury and/or dysfunction.
        Chronic cardio-renal syndrome (type 2): chronic abnormalities in heart function (CHF-CHD)
        leading to kidney injury and/or dysfunction. Acute reno-cardiac syndrome (type 3): acute
        worsening of kidney function (AKI) leading to heart injury and/or dysfunction. Chronic
        reno-cardiac syndrome (type 4): chronic kidney disease leading to heart injury, disease,
        and/or dysfunction. Secondary CRS (type 5): systemic conditions leading to simultaneous
        injury and/or dysfunction of heart and kidney.
        Exclusion Criteria:
        Pregnant or breastfeeding women; Female patients with recent birth plans; Patients who
        cannot follow up on medications.

Study details
    Heart Failure
    Kidney Diseases
    Kidney Injury
    Heart Valve Diseases
    Dialysis; Complications
    Coronary Heart Disease

NCT05397392

Nanjing First Hospital, Nanjing Medical University

27 January 2024

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