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In-depth Immunological Investigation of COVID-19.

In-depth Immunological Investigation of COVID-19.

Recruiting
18 years and older
All
Phase N/A
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Overview

The COntAGIouS trial (COvid-19 Advanced Genetic and Immunologic Sampling; an in-depth characterization of the dynamic host immune response to coronavirus SARS-CoV-2) proposes a transdisciplinary approach to identify host factors resulting in hyper-susceptibility to SARS-CoV-2 infection, which is urgently needed for directed medical interventions.

Description

The overall aim of this prospective study is to provide an in-depth characterization of clinical and immunological features of patients hospitalized in UZ Leuven because of SARS-CoV-2 infection. For this purpose, clinical data and blood, nasopharyngeal/rectal swab, and if safe, bronchoalveolar lavage (BAL) fluid and lung tissue samples will be collected from PCR- or CT-confirmed COVID-19 patients, with varying degrees of disease severity. Assessed characteristics will be compared between severe and non-severe COVID-19 patients, and between COVID-19 positive and negative ('control') patients.

Eligibility

Inclusion Criteria:

  • Patients >/= 18 years old AND
  • Hospitalised with PCR-confirmed and/or CT-confirmed SARS-CoV-2 disease

Exclusion Criteria:

  • Age < 18 years old
  • No informed consent

Study details
    Coronavirus Infections

NCT04327570

Universitaire Ziekenhuizen KU Leuven

27 January 2024

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