Overview
- Hypothesis
Prucalopride can mimic electrical stimulation of the abdominal vagus nerve and has an anti-inflammatory effect.
- Aims
In the present pilot study, the investigators want to evaluate the anti-inflammatory effect of prucalopride. The following aims are formulated:
- to show that prucalopride has a similar inflammatory effect as abdominal vagus nerve stimulation (VNS)
- to evaluate whether prucalopride leads to accelerated post-operative recovery
Eligibility
Inclusion Criteria:
- patients undergoing partial or full resection of the pancreas due to a benign or malignant tumor
Exclusion Criteria:
- adjuvant radiotherapy
- evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis)
- chronic pancreatitis
- pancreatic polypeptide producing endocrine tumor
- American Society of Anesthesiologists physical-health status classification (ASA-PS)>3
- Poorly regulated diabetes (>200 mg/dl (=11 mmol/l))