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Soluble B7-H3 as a Biomarker for Osteosarcoma

Soluble B7-H3 as a Biomarker for Osteosarcoma

Recruiting
12 years and older
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies. However, the level of sB7-H3 and its clinical significance in osteosarcoma are not well known. In this present study, we investigated whether sB7-H3 levels in serum could be as a biomarker for osteosarcoma treatment.

Eligibility

Inclusion Criteria:

  • High Grade osteosarcoma verified with pathologic diagnosis.
  • systemic treatment-naive before the first time Blood drawing.
  • ECOG 0 or 1 and all the other imagings indicate that patients could tolerate standard PKUPH-OS-02 protocol neoadjuvant chemotherapy.
  • All radiographs are complete for clinical evaluation.

Exclusion Criteria:

  • Patients who Can't tolerate blood drawing.
  • Patients without complete medical records in PKUPH system.
  • Patients who can't tolerate PKUPH-OS-02 neoadjuvant chemotherapy.
  • other conditions that investigators think are not suitable for this study.

Study details
    Biomarker
    Progression
    Osteosarcoma
    Surveillance

NCT05942456

Peking University People's Hospital

22 May 2024

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