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Exploring the Preventive Effect of Mitochondrial Protective Agent Idebenone on Post-stroke Epilepsy

Exploring the Preventive Effect of Mitochondrial Protective Agent Idebenone on Post-stroke Epilepsy

Recruiting
18-80 years
All
Phase 4

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Overview

According to the random number table, all patients were divided into short-term treatment group, long-term treatment group and non-intervention stroke control group according to the proportion of (1:1:1) epilepsy disease modifier idebenone. Patients in the short-term treatment group will take idebenone for a total course of 14 days (acute period) after stroke, and patients in the long-term treatment group will take idebenone for a total course of 3 months after stroke.

Eligibility

Inclusion Criteria:

  • Patients admitted to hospital within 24 hours of stroke symptoms and diagnosed with stroke (including cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage, intracranial venous sinus thrombosis, etc.) after relevant examinations;
  • Able to cooperate with the inspection;
  • Sign the informed consent form.

Exclusion Criteria:

  • History of epilepsy before stroke;
  • A history of serious comorbidities that may lead to seizures (including malignant tumors, specific autoimmune diseases, severe electrolyte abnormalities, end-stage renal disease, and severe head trauma);
  • Secondary stroke caused by head trauma or surgery;
  • Other patients that the researchers think need to be excluded.

Study details
    Post Stroke Epilepsy

NCT05987397

Xiangya Hospital of Central South University

27 January 2024

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