Overview
To learn whether giving spinal stereotactic radiosurgery (SRSS) that uses a more advanced imaging scan method called Magnetic Resonance imaging with a Linear Accelerator (MR-LINAC) during treatment will lead to improved responses to treatment and better quality of life. SRSS is radiation therapy given to the area around your spine.
Description
Primary objective:
• To determine the 6-month local control (LC) of the target site of treatment.
Secondary Objectives:
- To determine the 6-month change in epidural tumor volume (by volumetric measurements where applicable)
- To determine the 1-year local control of the target site
Eligibility
INCLUSION CRITERIA:
- Age ≥ 18 years old
- Radiographically documented disease of the spine within 4 weeks of registration (candidates with or without epidural disease allowed)
- Candidate for spine SRS/SBRT as determined by treating Radiation Oncologist or Multidisciplinary Spine Conference review
- Maximum of 3 contiguous vertebral levels involved with metastasis in the spine to be irradiated allowed
- Diagnosis of cancer documented
- Motor strength ≥ 4 out of 5 in the extremity affected by the level of spinal disease planned for radiation
- Karnofsky Performance score (KPS) ≥ 40 or ECOG score ≤ 3
EXCLUSION CRITERIA:
- Patients with highly radiosensitive histologies likely to respond to conventional radiation therapy alone (ie lymphoma, multiple myeloma, etc)
- Patients who are unable to undergo MRI of the spine with contrast
- Patients who are pregnant