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Fluoride Delivery to Prevent White Spots During Orthodontic Treatment

Fluoride Delivery to Prevent White Spots During Orthodontic Treatment

Recruiting
11-16 years
All
Phase 4

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Overview

The aim of this 2-armed, parallel, randomised, controlled trial is to assess the effect of different ways of applying fluoride to teeth on the formation of white spots (enamel demineralisation), during orthodontic treatment with fixed metal braces, in children and adolescents.

Description

One of the most common side-effects and risks of orthodontic treatment with fixed (metal) braces is damage to the outer surface (enamel) of the teeth. This damage can take the form of white or brown spots on the teeth (white spot lesions; WSLs) or if severe, holes in the teeth that need a filling.

The aims of this study are to find out the best way of preventing damage to the teeth of children and adolescents who are under going orthodontic treatment with fixed (metal) braces.

The participants will be 130 children, aged 11-16 years old, inclusive. The participants will be split into two groups using a process called randomisation. The treatments will be standard fluoride toothpaste (Colgate) and either:

  1. Fluoride mouth wash (Fluorigard) or
  2. Tooth Mousse Plus

The participants' teeth will be checked at every visit and the brace adjusted. Photographs of the participants' teeth will be taken very 3 months to see if any of the teeth have been damaged. The participants will be asked about the impact of their teeth on their life. Participants and parents will be asked about the impact of any white spots that form on the participants' teeth during the treatment with fixed (metal) braces.

The study will follow the participants through the whole length of treatment which will take about 2 years.

Eligibility

Inclusion Criteria:

  • Planned to receive orthodontic treatment with upper and lower fixed orthodontic appliances (braces) either alone or following a period of functional appliance treatment.
  • 11-16 years of age inclusive at the start of the fixed orthodontic appliance treatment.
  • All genders.
  • Fit and well with no chronic disease necessitating regular hospital follow-up at hospital.
  • Willing to participate

Exclusion Criteria:

  • Significant disabilities that may affect manual dexterity;
  • Any medical complication that would contraindicate the use of the fluoride treatments or milk products;
  • Previous orthodontic treatment except Phase I functional appliance treatment;
  • From areas that have fluoridated water supply*;
  • Full coronal coverage restorations;
  • More than 2 missing anterior teeth;
  • Showing signs of systemic illness e.g. fever, cough, loss of taste/smell;
  • Any abnormality of face, lips e.g. cleft lip and/or palate or craniofacial abnormality or soft tissues of the mouth e.g. aphthous ulcers or connective tissue disorder.

Study details
    Orthodontic Appliance Complication
    Tooth Demineralization

NCT05005689

Liverpool University Hospitals NHS Foundation Trust

27 January 2024

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