Overview
Dynamic 99mTc-Tetrofosmin CZT-SPECT myocardial perfusion imaging (MPI) is an advanced functional imaging technique giving important myocardial flow quantification added data in comparison with conventional MPI, especially in coronary multi vessel disease. A large-scale validation of diagnostic performances of myocardial flow reserve (MFR) estimated with Dynamic 99mTc-Tetrofosmin CZT-SPECT MPI would allow a non-invasive approach instead of invasive intra-coronary fractional flow reserve (FFR) measurement. The aim of this prospective study is to assess diagnostic performances of MFR calculated with dynamic 99mTc-Tetrofosmin CZT-SPECT MPI in comparison with invasive intra-coronary FFR measurement in patients with significant residual coronary arteries stenosis after ST-elevation myocardial infarction.
Eligibility
Inclusion Criteria:
- Adult patient.
- Multi vessel coronary arteries disease (at least one non-culprit coronary stenosis >= 50%) diagnosis during primary percutaneous coronary intervention < 12h after ST-elevation myocardial infarction.
- Written consent.
- Social security affiliation
Exclusion Criteria:
- Non adult patient.
- Adult patient under tutelage.
- Reproductive age women.
- Medical history of myocardial infarction or coronary artery bypass surgery.
- Cardiogenic shock.
- Cardiomyopathy.
- Regadenoson/adenosine/FFR contraindication.
- 99mTc-Tetrofosmin hypersensibility.
- Small non-culprit coronary arteries.
- Participation to another interventional study.