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Pain Phenotyping in Knee OA: a Pilot Trial

Recruiting
18 years of age
Both
Phase N/A

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Overview

Osteoarthritis (OA) is disease in which the joint breaks down, causing pain. The decision to surgically replace the knee, a procedure called total knee arthroplasty (TKA), depends on x-ray results as well as pain and dysfunction. Despite TKA resulting in good outcomes for most patients, between 1 in 10 and 1 in 5 patients remain in significant pain - i.e., are 'TKA non-responders'. Two pain conditions - myofascial pain syndrome (MPS) and central sensitization - frequently coexist with signs of OA and may contribute to a TKA non-responder profile. MPS, caused by knots within skeletal muscle, can contribute to an OA patient's pain and dysfunction. In central sensitization, faulty pain sensing leads to increased pain sensitivity. However, there is currently no established process to identify these sources of pain and potential associated TKA non-responder risk. Our research aims conduct a pilot study to examine the impact of pain diagnosis tools to help orthopedic surgeons identify potential TKA nonresponders. This new approach may increase healthcare efficiency (reduce TKA waitlist and length of hospital stay), and help patients receive the right care at the right time.

Eligibility

Inclusion Criteria:

  • adult patients aged 18 or older
  • on the waitlist for TKA (unilateral) for knee osteoarthritis

Exclusion Criteria:

  • undergoing revision or non-elective surgery
  • unable to provide informed consent and follow study procedures

Study details

Osteo Arthritis Knee, Chronic Post-operative Pain

NCT06066684

University Health Network, Toronto

27 January 2024

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