Overview
The purpose of this study is to develop and refine techniques for using magnetic resonance and optical spectroscopy to investigate how your body uses energy.
Description
Primary Study Objective:
To evaluate the reproducibility of acquiring multi-nuclear data on a new 3T Philips Magnet in conjunction with Optical Spectroscopy.
Eligibility
Inclusion Criteria:
- Male or female
- Age 18 - 89
- Healthy (self assessed)
- Weight under 350lbs
- Able to walk 50 yards without stopping
- Able to travel to hospital for study visits
- Able to follow a 3-step command
- Able to remain in magnetic resonance (MR) scanner for up to 2 hours
Exclusion Criteria:
- Have internal metal medical devices, including cardiac pacemakers, aortic or cerebral aneurysm clips, artificial heart valves, ferromagnetic implants, shrapnel, wire sutures, joint replacements, bone or joint pins/rods/screws, metal fragments in your eye, or non-removable jewelry such as rings.
- Are unwilling or unable to complete the imaging procedures for the duration of the magnetic resonance imaging (MRI) scan due to claustrophobia or other reason.
- Serious mental illness that might preclude subject's ability to comply with study treatment
- Are pregnant or plan on becoming pregnant in the next 8 weeks.
- History of deep vein thrombosis (DVT) or pulmonary embolism (PE)
- Varicose Veins
- Known genetic factor (Factor V Leiden, etc.) or hypercoagulable state, including cancer, leukemia - such as chronic myelocytic leukemia (CML), hemoglobinopathies - such as sickle-cell disease and multiple myeloma and other proteinopathies.
- Diagnosed peripheral arterial or vascular disease
- Family history of primary DVT or PE
- Peripheral neuropathy
- History of chronic venous stasis or lower extremity edema
- Female taking hormonal birth control (oral or otherwise) AND smoker