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Secondary Obliteration of Old Radical Cavities Using S53P4 Bioactive Glass

Secondary Obliteration of Old Radical Cavities Using S53P4 Bioactive Glass

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Overview

In canal wall down surgeries, the posterior bony wall of the external auditory canal (EAC) is removed to increase exposure. The creation of a so-called radical cavity comes with several possible disadvantages, such as higher rates of postoperative otorrhea and purulence, pain, adherence to water precautions and dizziness. Secondary obliteration of the mastoid cavity and reconstruction of the posterior wall of the EAC can help alleviate these symptoms. Our goal is to study the efficacy of secondary obliteration using S53P4 bioactive glass as obliteration material. This bioactive glass has several important characteristics, such as retaining of volume over time and antibacterial effects. The main outcome will be postoperative otorrhea as indicated by the Merchant grading scale.

Eligibility

Inclusion Criteria:

  • Old canal wall down cavity
  • Operated between 2011 and 2022

Exclusion Criteria:

  • Middle ear cholesteatoma
  • Previous obliteration

Study details
    Mastoid Cavity

NCT06116513

Diakonessenhuis, Utrecht

14 October 2025

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