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Prednisolone Treatment in Acute Interstitial Nephritis

Prednisolone Treatment in Acute Interstitial Nephritis

Recruiting
18 years and older
All
Phase 4
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

A Prospective randomized trial with a primary objective to investigate the effect ofprdenisolone treatment in acute interstitial nephritis

Eligibility

Inclusion Criteria:

  • Biopsy verified AIN
  • Clinical suspicion of AIN
  • Age > 18 years
  • One of following criteria:
    • Plasma creatinine > 120 µmol/L or
    • Plasma creatinine increase > 30 µmol/L or increase > 50 % of baseline plasma creatinine
  • Fertile women are included

Exclusion Criteria:

  • No ability to give informed consent
  • Immunosuppressive treatment (including prednisolone) within 3 months before biopsy
  • Autoimmune disease
  • Prednisolone intolerance
  • Pregnancy or lactation
  • Active cancer (except basal cell carcinoma)
  • Short life expectancy (< 6 months)
  • CKD stage IV-V
  • AIN secondary to or accompanied by glomerulonephritis, sarcoidosis or inherited interstitial renal disease
  • Previous participation Withdrawal criteria
  • Development of exclusion criterion
  • Withdrawal of consent

Study details
    Acute Tubulo-Interstitial Nephritis

NCT04376216

Region MidtJylland Denmark

27 January 2024

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