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Intratumor CpG-ODN Injection Boosters Immune Killing Against in Situ Tumor Antigen Release for Advanced Solid Tumors

Intratumor CpG-ODN Injection Boosters Immune Killing Against in Situ Tumor Antigen Release for Advanced Solid Tumors

Recruiting
18-80 years
All
Phase 1
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Overview

To study the safety and clinical effects of intratumor injecting CpG-ODN and in situ release of tumor antigen by interventional ablation or drug-eluting beads to treat advanced solid tumors.

Description

  1. Percutaneous microwave ablation or intratumor injection of drug-eluting beads to destroy cancer cells to release tumor-specific antigens
  2. Intratumor injection of type A/C CpG-ODN with or without infusion of CAR-T cells secreting scFv against OX40
  3. Assessing side effects and therapeutic efficacy after the combined treatments

Eligibility

Inclusion Criteria:

  • Solid advanced malignant tumors
  • Age between18 and 80 years
  • Life expectancy is greater than three months

Exclusion Criteria:

  • Benign tumor
  • Life expectancy is less than three months
  • Serious medical comorbidity
  • Others

Study details
    Lung Cancer
    Hepatocellular Carcinoma
    Solid Tumor

NCT04952272

Second Affiliated Hospital of Guangzhou Medical University

27 January 2024

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