Cladribine Combined With G-CSF and Cytarabine as a Salvage Treatment in R/R ALL

Overview

To explore the efficiency and safety of CLAG regimen in R/R ALL

Description

R/R Acute Lymphoblastic Leukemia has poor response to second-line chemotherapy.Here,we want to explore efficiency and safety of CLAG regimen in R/R ALL.

Eligibility

Inclusion Criteria:

        The patients meet the diagnostic criteria for Relapsed/Refractroy B-ALL. ECOG score is 0-3.
        Expecting life span is more than 6 weeks.
        Exclusion Criteria:
        Patients are combined with severe organ dysfunction or organ failure: Cardiac failure,
        Liver and kidney insufficiency.
        Patients are combined with severe infection or other complications that can not tolerate
        chemotherapy.
        Patients are considered as other tumor progression. Patients have used cladribine. Pregnant
        and lactating women will not be included.